Aims & Results of the NWTS Clinical Trials 

Study

Years of Registration

Total Registrations

NWTS-1

October 1969 to February 1975

741

NWTS-2

January 1975 to April 1979

950

NWTS-3

May 1979 to September 1986

2496

NWTS-4

August 1986 to August 1995

3335

NWTS-5

August 1995 to May 2002

3031

 

The National Wilms Tumor Study (NWTS) was created in 1969 to address the need to study and compare treatments in an efficient period of time.  With only 500 cases of Wilms diagnosed annually, a single institution or several combined institutions could not complete an investigation in a relatively short period of time as they would not have enough patients to make significant comparisons.   Groups of investigators and institutions interested in improving treatment for Wilms tumor agreed to combine their efforts and contribute data to the newly formed NWTS.  Their goal was to combine information on relatively large number of patients so that early answers could be identified to long-standing questions regarding therapy.

In addition to analyzing the results of the initial aims, NWTS researchers identified a variety of elements that at diagnosis would help physicians gauge each patients risk for untoward outcomes.  These “prognostic factors” publications have resulted in better treatment outcomes based upon such factors as tumor stage and histology, surgical and pathology findings, and patient age.

Each study identified objectives which always included the original objectives to improve treatment and outcome and to identify therapies that progressively eliminated or decreased long-term affects on the health of survivors.  Each new study was built on the results of the previous study.  Each new study resulted in improvements in treatments and in the long-term health of patients.  The first protocol in 1969 identified diminishing late effects as a significant purpose of the NWTS.

From the beginning the NWTS overriding principle has been “Cure is not enough.”  In 1991 we received NIH funding for the Late Effects Study to become an activity independent from the clinical trials.  That was the year NWTS co-founder Dr. Audrey Evans published our first comprehensive analyses of finding to date: Late Effects of Treatment for Wilms Tumor: A Report from the National Wilms Tumor Study Group.

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NWTS-1

Aims

Results

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NWTS-2

Aims

Results

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NWTS-3

Aims

Results

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NWTS-4

Aims

Results

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NWTS-5

Aims

Results

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About the NWTS Participants, Family & Friends Newsletters Contact Us Institutions Bibliography
National Wilms Tumor Study
Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N, M2-A876,
PO Box 19024, Seattle, WA 98109-1024
Phone: (206) 667-4842 or (800) 553-4878
FAX: (206) 667-6623
Email: nwtsg@fredhutch.org
Mission Statement Aims & Results of the NWTS Clinical Trials The NWTS Founders The Late Study Who was Max Wilms

History of the NWTS

NWTS